Dermal penetration and systemic level

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Thus, since a trustable toxicity study by dermal absorption lacks, risk factors through dermal exposure of pesticides have been evaluated by supplementing the uncertainty due to the difference of the route of administration. In detail, selection of the solution depends on whether the tissue used in the experiment has living physiological activity or dead tissue without metabolic activity. When the exposure level is higher than AOEL, the pesticide cannot be approved. This is because, in the most of the skin tissue without physiological activity used in the rate experiment, absorption through the blood vessels does not occur, so the test substances have accumulated in the skin tissue to exist in a high concentration. Skin disease dermatitis is considered one of the most common occupational diseases. The end result should be performed on these roundings, in case of result value calculation using Triple pack. J Toxicol Environ health. End of the experiment and calculation of absorption rate. Exposure modeling depends on several factors and assumptions.


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